miRNA Signature of Mouse Helper T Cell Hyper-Proliferation
نویسندگان
چکیده
منابع مشابه
miRNA Signature of Mouse Helper T Cell Hyper-Proliferation
Helper T cells from a mutant mouse model, LAT Y136F, hyper-proliferate and cause a severe lymphoproliferative disease that kills the mice by six months of age. LAT Y136F mice carry a tyrosine to phenylalanine mutation in the Linker for Activation of T cells (LAT) gene. This mutation leads to a number of changes in T cells that result in altered cytokine production including increased IL-4 produ...
متن کاملTwo Types of Mouse T Helper Cell
Many long-term mouse Th cell clones can be divided into two types, based on the pattern of cytokines secreted in response to antigen or lectin stimulation . Thl clones secrete IL-2, IFN-y, and lymphotoxin (LT),' whereas Th2 clones express IL4, IL-5, IL-6, and a gene of unknown function, P600 (1-4) . Both types of clone secrete IL-3, granulocyte-macrophage CSF (GM-CSF), TNFa, preproenkephalin, a...
متن کاملDifferential macrophage requirements for T helper cell and T helper cell-induced B lymphocyte proliferation
Major histocompatibility complex-restricted helper T cell clones against "minor" antigens expressed on B cell and macrophage surfaces, when confronted with appropriate T cell-depleted spleen cells, are induced to proliferation and, in turn, activate "target-responder" B cells to polyclonal growth and maturation. Irradiation of helper cell populations, however, demonstrates that their effector f...
متن کاملFollicular helper T cell signature in type 1 diabetes.
The strong genetic association between particular HLA alleles and type 1 diabetes (T1D) indicates a key role for CD4+ T cells in disease; however, the differentiation state of the responsible T cells is unclear. T cell differentiation originally was considered a dichotomy between Th1 and Th2 cells, with Th1 cells deemed culpable for autoimmune islet destruction. Now, multiple additional T cell ...
متن کاملJunD regulates lymphocyte proliferation and T helper cell cytokine expression.
Transgenic mice broadly expressing JunD (Ubi-junD(m)) appear phenotypically normal, but have strongly reduced numbers of peripheral lymphocytes. JunD overexpression in lymphocytes does not protect from numerous apoptotic insults; however, transgenic T cells proliferate poorly and exhibit impaired activation due to reduced levels of IL-4, CD25 and CD69. Consistently, in the absence of JunD (junD...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0066709